Sponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development. A panel of experts discuss supplier identification and selection, financial considerations, and the ethical issues. They cover contracting out laboratory analysis, data management, and statistical services, and the effects of outsourcing on quality assurance. Whether readers are beginning to explore the possibility of outsourcing or already involved in long-term strategic outsourcing partnerships, this invaluable resource is a complete guide to the drug development outsourcing relationship.

A complete guide to the drug development outsourcing relationship, sponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development. A panel of experts discuss supplier identification and selection, financial considerations, and the ethical issues. They cover contracting out laboratory analysis, data management, and statistical services, and the effects of outsourcing on quality assurance. Whether readers are just exploring the possibility of outsourcing or already involved in long-term strategic outsourcing partnerships, this book is an invaluable resource.

Butterworth-Heinemann s CIM Coursebooks have been designed to match the syllabus and learning outcomes of our new qualifications and should be useful aids in helping students understand the complexities of marketing. The discussion and practical application of theories and concepts, with relevant examples and case studies, should help readers make immediate use of their knowledge and skills gained from the qualifications. Professor Keith Fletcher, Director of Education, The Chartered Institute of Marketing Here in Dubai, we have used the Butterworth-Heinemann Coursebooks in their various forms since the very beginning and have found them most useful as a source of recommended reading material as well as examination preparation. Alun Epps, CIM Centre Co-ordinator, Dubai University College, United Arab EmiratesButterworth-Heinemann s official CIM Coursebooks are the definitive companions to the CIM professional marketing qualifications. The only study materials to be endorsed by The Chartered Institute of Marketing (CIM), all content is carefully structured to match the syllabus and is written in collaboration with the CIM faculty. Now in full colour and a new student friendly format, key information is easy to locate on each page. Each chapter is packed full of case studies, study tips and activities to test your learning and understanding as you go along. The coursebooks are the only study guide reviewed and approved by CIM (The Chartered Institute of Marketing). Each book is crammed with a range of learning objectives, cases, questions, activities, definitions, study tips and summaries to support and test your understanding of the theory. Past examination papers and examiners reports are available online to enable you to practise what has been learned and help p

'Butterworth-Heinemann's CIM Coursebooks have been designed to match the syllabus and learning outcomes of our new qualifications and should be useful aids in helping students understand the complexities of marketing. The discussion and practical application of theories and concepts, with relevant examples and case studies, should help readers make immediate use of their knowledge and skills gained from the qualifications.' Professor Keith Fletcher, Director of Education, The Chartered Institute of Marketing 'Here in Dubai, we have used the Butterworth-Heinemann Coursebooks in their various forms since the very beginning and have found them most useful as a source of recommended reading material as well as examination preparation.' Alun Epps, CIM Centre Co-ordinator, Dubai University College, United Arab Emirates Butterworth-Heinemann's official CIM Coursebooks are the definitive companions to the CIM professional marketing qualifications. The only study materials to be endorsed by The Chartered Institute of Marketing (CIM), all content is carefully structured to match the syllabus and is written in collaboration with the CIM faculty. Now in full colour and a new student friendly format, key information is easy to locate on each page. Each chapter is packed full of case studies, study tips and activities to test your learning and understanding as you go along. *The coursebooks are the only study guide reviewed and approved by CIM (The Chartered Institute of Marketing). *Each book is crammed with a range of learning objectives, cases, questions, activities, definitions, study tips and summaries to support and test your understanding of the theory. *Past examination papers and examiners' reports are available online to enable you to practise what has been learned and help prepare for the exam and pass first time. *Extensive online materials support students and tutors at every stage. Based on an understanding of student and tutor needs gained in extensive research, brand new online materials have been designed specifically for CIM students and created exclusively for Butterworth-Heinemann. Check out exam dates on the Online Calendar, see syllabus links for each course, and access extra mini case studies to cement your understanding. Explore marketingonline.co.uk and access online versions of the coursebooks and further reading from Elsevier and Butterworth-Heinemann. INTERACTIVE, FLEXIBLE, ACCESSIBLE ANY TIME, ANY PLACE www.marketingonline.co.uk

This book offers a thesis about the interests underlying the Epistle. Dr Hughes argues that the major concern of the author has been to achieve a theological understanding of the relationship between the now out-moded forms and institutions of Old Testament worship and those of the distinctively new (yet not unrelated) Christian faith in which he now finds himself.

How, in this age of belief, can we make sense of the act of Christian worship? Convinced that people shape their meanings from those available to them, Graham Hughes inquires into liturgical constructions of meaning, within the larger context of late twentieth-century meaning theory. Drawing particularly upon the work of Charles Peirce, Hughes employs semiotic theory to analyze the construction, transmission and apprehension of meaning within an actual worship service. This book will appeal to teachers and students of theology, clergy and informed lay Christians.

How, in this age of belief, can we make sense of the act of Christian worship? Convinced that people shape their meanings from those available to them, Graham Hughes inquires into liturgical constructions of meaning, within the larger context of late twentieth-century meaning theory. Drawing particularly upon the work of Charles Peirce, Hughes employs semiotic theory to analyze the construction, transmission and apprehension of meaning within an actual worship service. This book will appeal to teachers and students of theology, clergy and informed lay Christians.

Sjoegren's Syndrome is slowly being recognised as one of the most common auto-immune diseases, and considered pivotal in the spectrum of auto-immune disorders. Sjoegren's Syndrome in Clinical Practice is a unique, concise book which explores important insights into Sjoegren's links with other conditions and devotes itself to shedding new light on this disease. Aimed at young medics but also suitable for the informed lay reader, physicians and pharma, Sjoegren's Syndrome in Clinical Practice will help with the diagnosis and treatment of this increasingly recognised disorder.

There is no book like it Complete the journey from pedestrian to excellent driver. Concise and easy to read Buy all your driving lessons for the price of this book. Use my SYSTEM and pass your practical driving test without paying for a single lesson. This book is essential if you want to pass your driving test the first time. Take your time to get things right and work at your own pace. Check your problems with the Problem pages. On average, less than 50% of pupils trained by a driving instructor in the UK, pass the driving test. Who are the driving instructors with a pass rate under 50%? None of us knows Why pay for driving lessons when you do not know whether you are going to pass the test? Buy this book instead. IMPORTANT The helper must not charge for lessons. If you do, you are committing a serious offence. You are not a Registered Driving Instructor. These are the only people that can charge for driving lessons.

Clinician s Manual on Lupus is an expert overview of Lupus and related conditions that serves as an educational resource for medical students, physicians and other medical professionals with an interest in rheumatology. The book is an up-to-date introduction to the disease and includes high quality colour photographs and evidence-based guidelines for diagnosing, treating and managing Lupus in primary care."

This book contains information on an increasingly common autoimmune disorder. Also called "sticky blood" and Hughes Syndrome, APS makes one's blood clot too easily, creating high risk of stroke, thrombosis, and premature heart attack. It is also implicated in many other health problems including repeated miscarriages, neurological problems, eary dementia and migraines. It is often associated with lupus, and mimics the symptoms of other diseases, including MS.
Symptoms include; migraines and headaches, recurrent miscarriage, memory loss, slurred speech, blood clots, poor circulation, muscle pain and cramps, blurred vision, extreme fatigue, epilepsy, strokes, thrombosis and a form of angina. Because of lack of knowledge of APS in the medical establishment, sufferers are often misdiagnosed with MS or other more life-threatening conditions.
This book helps the reader identify the symptoms and provides important information on diagnosis and treatment of APS. It contains many moving stories, explaining how people eventually got a diagnosis, their symptoms, the impact of APS on their lives and whether or not treatment has worked.
Written in collaboration with Dr. Graham Hughes, the major researcher of APS in the UK, this book provides a clearly written informative look at an important but little-known disease.

Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: * responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) * responsible for 1 in 5 young (under 45) strokes * a major cause of early heart attacks * responsible for 1 in 5 deep vein thromboses * an important cause of migraine. Hughes Syndrome: Highways and Byways is a valuable resource for professionals with an interest in the subject, as well as general practitioners and patients. .

Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students provides an in-depth analysis into the main effects of Hughes Syndrome. In 1983, Dr Graham Hughes, and his team in London, described a syndrome and subsequently developed simple blood tests to diagnose the condition. This syndrome is characterised by thrombosis (both in limbs and internal organs), headaches, memory loss, strokes and, in pregnant women, placental clotting and recurrent miscarriage. The syndrome, now known worldwide as Hughes Syndrome, or the Antiphospholipid Syndrome, is common - being responsible for example, for up to 1 in 5 cases of young stroke and more importantly, it is treatable. Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students details the effects of Hughes Syndrome on the major organs, making it a valuable reference tool for students in training.

Lupus is an extremely common, potentially treatable, disease of the immune system. It affects approximately 1 in 1000 women and is more common than diseases such as multiple sclerosis and leukaemia. Despite this, there is little information concerning the disease in contrast to other illnesses of similar prevalence.

Many people are unaware of the symptoms, treatment, and prevention of lupus. It is important that these topics are highlighted for many reasons. For example, a greater understanding of the symptoms of lupus will enable patients to recognise the symptoms earlier, and get treatment faster; before any serious damage is done. Similarly, awareness of preventative measures may reduce the number of cases of lupus that occur.

From a different perspective, it would be of great use to have an easily accessible source of information available to lupus patients that would highlight issues such as treatment options and sources of support.

In summary, although knowledge of lupus is growing, greater awareness of the disease amongst both patients and the general public is an issue that needs to be addressed.

Along with AIDS, antiphospholipid syndrome was the major medical discovery of the late 20th century, so for many it is still deemed a 'new' disease.

The discovery of 'sticky blood' (commonly known as antiphospholipid syndrome or 'Hughes Syndrome') came out of years of observation of patients who had developed lupus. Many specialists in the 1970s were interested in the neurological aspects of lupus, and Dr Hughes, among others, spent a number of years studying the mechanisms of brain inflammation.

In the mid 1970s, Hughes observed a number of young women with a form of viral paralysis, where interestingly many of them carried an antibody in their blood actually directed against 'phospholipid' - one of the components of brain and spinal cord. It quickly became apparent that individuals who had "anti-phospholipid antibodies" suffered from a tendency not only to develop brain and spinal cord symptoms, but also a tendency to develop both vein and artery thrombosis.

As investigation continued it became apparent that these symptoms were not just confined to lupus patients, but occurred in others too, specifically those with severe migraines, with repeated strokes, with memory loss, and in women with recurrent miscarriage.

This book offers a thesis about the interests underlying the Epistle. Dr Hughes argues that the major concern of the author has been to achieve a theological understanding of the relationship between the now out-moded forms and institutions of Old Testament worship and those of the distinctively new (yet not unrelated) Christian faith in which he now finds himself.

This study text focuses on marketing communications. It is part of a range of CIM study texts which carry the full recommendation of the CIM examiners.